Saturday, June 13, 2009

Imperial rising...come on Imperial!

Discover the top 100 universities in the world from the THE - QS World University Rankings.

2007 Rank2006 RankSchool NameCountry
Source: QS Quacquarelli Symonds (www.topuniversities.com)
Copyright © 2004-2007 QS Quacquarelli Symonds Ltd.
Click here for copyright and limitations on use.
11HARVARD UniversityUnited States
2=2University of CAMBRIDGEUnited Kingdom
2=3University of OXFORDUnited Kingdom
2=4YALE UniversityUnited States
59IMPERIAL College LondonUnited Kingdom
610PRINCETON UniversityUnited States
7=7CALIFORNIA Institute of Technology (Calt...United States
7=11University of CHICAGOUnited States
925UCL (University College London)United Kingdom
104MASSACHUSETTS Institute of Technology (M...United States
1112COLUMBIA UniversityUnited States
1221MCGILL UniversityCanada
1313DUKE UniversityUnited States
1426University of PENNSYLVANIAUnited States
1523JOHNS HOPKINS UniversityUnited States
1616AUSTRALIAN National UniversityAustralia
1719University of TOKYOJapan
1833University of HONG KONGHong Kong
196STANFORD UniversityUnited States
20=35CARNEGIE MELLON UniversityUnited States
20=15CORNELL UniversityUnited States
228University of California, BERKELEYUnited States
2333University of EDINBURGHUnited Kingdom
2446KING'S College LondonUnited Kingdom
2529KYOTO UniversityJapan
2618École Normale Supérieure, PARISFrance
2722The University of MELBOURNEAustralia
2837ÉCOLE POLYTECHNIQUEFrance
2942NORTHWESTERN UniversityUnited States
3040University of MANCHESTERUnited Kingdom
3135The University of SYDNEYAustralia
3254BROWN UniversityUnited States
33=50University of BRITISH COLUMBIACanada
33=19National University of SINGAPORE(NUS)Singapore
33=45University of QUEENSLANDAustralia
3614PEKING UniversityChina
3764University of BRISTOLUnited Kingdom
38=29University of MICHIGANUnited States
38=50The CHINESE University of Hong KongHong Kong
4028TSINGHUA UniversityChina
4131University of CALIFORNIA, Los Angeles (U...United States
4224ETH Zurich (Swiss Federal Institute of T...Switzerland
4338MONASH UniversityAustralia
4441University of NEW SOUTH WALESAustralia
4527University of TORONTOCanada
4670OSAKA UniversityJapan
4766BOSTON UniversityUnited States
4869University of AMSTERDAMNetherlands
4943NEW YORK University (NYU)United States
5046The University of AUCKLANDNew Zealand
51=32University of TEXAS at AustinUnited States
51=63SEOUL National UniversityKorea, South
53=58HONG KONG University of Science & Techno...Hong Kong
53=78TRINITY College DublinIreland
55=79University of WISCONSIN-MadisonUnited States
55=84University of WASHINGTONUnited States
5773University of WARWICKUnited Kingdom
5844University of CALIFORNIA, San DiegoUnited States
5917LONDON School of Economics and Political...United Kingdom
6058HEIDELBERG UniversitätGermany
6196Katholieke Universiteit LEUVENBelgium
62105University of ADELAIDEAustralia
6386DELFT University of TechnologyNetherlands
64111The University of WESTERN AUSTRALIAAustralia
65=90University of BIRMINGHAMUnited Kingdom
65=98Ludwig-Maximilians-Universität MünchenGermany
6782Technische Universität MÜNCHENGermany
68102University of SHEFFIELDUnited Kingdom
6961NANYANG Technological UniversitySingapore
7085University of NOTTINGHAMUnited Kingdom
71=111UPPSALA UniversitySweden
71=61DARTMOUTH CollegeUnited States
7377University of ILLINOISUnited States
74=56EMORY UniversityUnited States
74=124University of YORKUnited Kingdom
76109University of ST ANDREWSUnited Kingdom
77=127PURDUE UniversityUnited States
77=88University of PITTSBURGHUnited States
79111University of MARYLANDUnited States
80=141University of SOUTHAMPTONUnited Kingdom
80=121University of LEEDSUnited Kingdom
8253VANDERBILT UniversityUnited States
8381University of GLASGOWUnited Kingdom
8490LEIDEN UniversityNetherlands
85=87University of VIENNAAustria
85=116FUDAN UniversityChina
85=60CASE WESTERN RESERVE UniversityUnited States
88176QUEEN'S UniversityCanada
8995UTRECHT UniversityNetherlands
90=99PENNSYLVANIA STATE UniversityUnited States
90=118TOKYO Institute of TechnologyJapan
92102RICE UniversityUnited States
93=181Université de MontréalCanada
93=54University of COPENHAGENDenmark
9548University of ROCHESTERUnited States
96170University of CALIFORNIA, DavisUnited States
97=145GEORGIA Institute of TechnologyUnited States
97=133University of ALBERTACanada
99141CARDIFF UniversityUnited Kingdom
100116University of HELSINKIFinland

Tuesday, June 09, 2009

Shhh! The biggest idea ever!



Charles Darwin had a big idea, arguably the biggest and best idea ever. And like all the best ideas it is beguilingly simple. In fact, it is so staggeringly elementary, so blindingly obvious, so amazingly ‘dud-duh why didn’t I think of that?’, that although others before him had had inklings of the truth, nobody thought to look for it in the right place. Darwin had 5 years to look for it; and he did so as the official naturalist onboard HMS Beagle - a sailing vessel that spent 5 years travelling the globe from Brazil to Tierra del Fuego - and from the Galapagos to the Malay Archipelago. When he arrived back in England Darwin sat on his idea for 20 years before finally telling the world about it. Why? Because he was scared. He knew it would change everything.

Darwin’s big idea is that of evolution by natural selection published in On the Origin of Species, that gave biology its guiding principle, a governing law that helps the rest make sense. Understanding its cold, beautiful logic is a must. If you want to understand life this is the place to start.

Natural selection's explanatory power is not just about life on this planet: it is the only theory so far suggested that could explain life on any planet. If life exists anywhere else in the universe then some version of evolution by natural selection will almost certainly turn out to underpin its existence. Darwin's theory works equally well no matter how strange and weird and wonderful that extraterrestrial life may be - and my tentative guess is that it will be weird beyond our wildest imaginings.

But what makes natural selection so special? A powerful idea assumes little to explain much. It does lots of explanatory 'heavy lifting', while expending little in the way of assumptions or postulations. It gives you plenty of bangs for your explanatory buck. Its Explanation Ratio - what it explains, divided by what it needs to assume in order to do the explaining - is enormous.

If any reader knows of any idea that has a larger explanation ratio than Darwin's, then I wanna hear it. Darwin's big idea explains all of life and its consequences, and that means everything that possesses more than minimal complexity – that includes you, and me, and the cat next door. It explains flowers and the bees that buzz about them. It explains mushrooms and HIV and athletes-foot-fungus. It even explains accountants. Now that’s what I call explaining! All this explaining is equal to the numerator of the explanation ratio, and it is huge.

Yet the denominator (the number at the bottom of the fraction) in the explanatory equation is spectacularly small and simple. The denominator is: natural selection, the non-random survival of genes in gene pools (to put it in neo-Darwinian terms rather than Darwin's own).

You can winnow Darwin's big idea down to a single sentence (again, this is a modern way of putting it, not quite Darwin's): 'Given sufficient time, the non-random survival of hereditary entities will generate complexity, diversity, beauty, and an illusion of design so persuasive that it is almost impossible to distinguish from deliberate intelligent design'. We don't need to add mutation to our assumptions. Mutational 'bucks' are provided free. 'Given sufficient time' is not a problem either - except for human minds struggling to take on board the terrifying magnitude of geological time. Look around you, the illusion of design is everywhere in the living world. So powerful is this illusion, so soft and comfortable and beguiling is the cotton wool over our eyes, that the spell of the illusion was only recently lifted 150 years ago today. Yes, 2009 is the 150th anniversary of Darwin's big idea - And our eyes are still accustomising to the brilliant new view.

It is mainly its power to simulate the illusion of design that makes Darwin's big idea seem threatening to a certain kind of mind. The same power constitutes the most formidable barrier to understanding it. People are naturally incredulous that anything so simple could explain so much. To a naive observer of the wondrous complexity of life, it just must have been intelligently designed.

But intelligent design is the polar opposite of a powerful theory: its explanation ratio is pathetically titchy. The numerator is the same as Darwin's: everything we know about life and its prodigious complexity. But the denominator, far from Darwin's slim and minimalist simplicity, is at least as big as the numerator itself: an unexplained intelligence, a ‘designer’ big enough to be capable of designing all the complexity we are trying to explain in the first place!

I'll end on a subtler legacy of Darwin's big idea. Darwin raises our consciousness to the sinewy power of science to explain the large and complex in terms of the small and simple. In biology we were fooled for centuries into thinking that extravagant complexity in nature needs an extravagantly complex explanation. Darwin triumphantly dispelled that delusion.

There remain deep questions in physics and cosmology that await their Darwin. Why are the laws of physics the way they are? Why are there laws at all? Why is there a universe at all? Why is there anything? Once again, the lure of 'design' is tempting. But we have the cautionary tale of Darwin before us. We've been through all that before. Darwin emboldens us - difficult as it is - to seek genuine explanations: explanations that explain more than they postulate. Darwin’s big idea is with us for good. There’s nothing quite like it to tear that wool from our eyes!


_____

Saturday, June 06, 2009

Coming soon...Life Trips

What is it like to be a spider threading a web or an eagle in flight? What is it like being a whale in depths or a pollen grain wafting above the earth? What is it like to be in love if you're a 200,000 year old human ancestor? Do you know love? Do you understand what it is? What is it like to be a drop of water recycling for a million years or a pebble burnished mercilessly by the tides? What is it like to be Homo erectus struggling to untangle the mystery of the moon? Is the moon far? If I climb that mountain can I touch it with my hands? What are these stars that dazzle me at night - are they fires from distant worlds? Where did she go, will I ever see her again? What is life? What is this? What is that? What is it all for?

Wednesday, June 03, 2009

L'art de BookWorming

Photobucket

Panoramic Karakoramic Highway - Pakistan


Photobucket

left-hand-side
Photobucket

right-hand-side
Photobucket

Crystal air views - misty morning dews - sleeping bag wet - slept all night - under starry canopy - meteor streaks venting - impossible things thought. Yawnings release me - tired muscles ache - i sleep & think of you - rustling warily - in my dream. Wake-up to - delicious ice cold - fresh mountain stream - breakfast of sip - of water only. Breakfast of water - and gulp of  morning air - i dream of - ice cold milk - drenched over cornflakes. A place like this - or cornflakes? I choose cornflakes - i hate my stomach - leave it behind - i wish i had. Mutinous sac of acid - spoiler of view - tormenter of me - causer of misery - wanter of cornflakes - which one's? Kelloggs!

Monday, June 01, 2009

Currently listening to... Album: 'Journal for Plague Lovers'

Photobucket



Song no 9 :  Doors closing slowly

The shadow is the cross ok - judgement must be willing today
Silence is not sacrifice - crucifixion is the easy life


[Video: Vagabond Productions (C)2009]



Song no 4 : This joke sport severed

This joke sport severed - I endeavoured
To find a place - where I became untethered


[Video: Vagabond Productions (C)2009]



JOURNAL FOR PLAGUE LOVERS by 'The Manic street preachers' - press Reviews:

Q - 'Simply a phenomenal rock record' *****

Uncut - 'A brave compelling record, stands shoulder to shoulder with The Manics best' ****

Sunday Times Culture - 'Great riff follows great riff.  A triumphant album' CD OF THE WEEK *****

Mojo - 'A band aligning with its purest impulses - A triumph' *****

The Fly - 'The Manic Street Preachers have re established themselves as one of the most important bands of our generation' **** ½

Maxim's Album Of The Month - 'The Welsh legends have well and truly found their voice again - This is essential'

Attitude - 'Stands up on its own as an angry, violent, unique piece of art'

Kerrang! - 'This is a record that HAD to be made, and it's an essential buy' KKKK

Independent On Sunday - 'The album of 2009 hands down no contest'

Clash Magazine - 'The spirits have lifted, the future is clear, welcome back Manic Street Preachers' 10/10

Observer Music Monthly - 'Not just a dignified salute to an absent friend but a cracking album in its own right' *****

The Guardian - 'A passionate rock album that honours the past, yet is very much of the present' *****

____

Friday, May 29, 2009

Eating The Sun


Here's what happened today. What really happened...


Photobucket



Dawn broke first over the Pacific. Because the international dateline bisects the largest ocean that's where the dawn always breaks first - planting its first kiss over the Pacific and perhaps on the prows of a few container ships. Then the dawn made landfall in the north a few hours later, sweeping a fiery multi-hued arc over the icy tundra, and at the end of the world to the south, it broke like a wave crashing against the mountains of New Zealand. Soon, effortlessly, it glided westwards; filling the rice paddies of the Philippines and the depths of the South China Sea. It touched-down in Thailand on the faces of the drivers sleeping in their tuk tuks. And everytime the sunlight hit something green - something truly green, not something painted green or dyed green: something with greenness that grew - the most amazing miracle on the planet began - anew

When the light of dawn shone on the greenness, the greenness smiled and welcomed it, and comprehended it, and put it to use. The greenness thrived and drank, nay gobbled up the dawn. The greenness was chlorophyll, a pigment. It was arranged such that the sunlight's energy bounced from one chlorophyll to the next like a frog across lily pads before reaching the subtle trap at the centre, the three billion year old trap where the light of the sun becomes the stuff of the earth. The stuff of life, the stuff of frogs, the stuff of you and me - even the stuff of love (if you want to stretch the metaphor to breaking point). As the trap's jaws snapped shut on the sunlight, the spring that powered those jaws pulled electrons from a nearby water molecule, breaking it up into hydrogen and oxygen. The hydrogen was used along with the stream of electrons to turn carbon dioxide into organic matter. The oxygen was discarded as waste into the air to be breathed in by us. In every plant reached by the dawn this extraordinary three billion year old mechanism came into life millions of times over. The carbon dioxide to which these electrons were channelled was turned first into sugar and then all sorts of other molecules. Some of these were used to thicken the plant stems, others to lengthen the leaves, to enrich the soil and to colour the flowers still held tight in their buds. Light made life: that is what photosynthesis means.

If the light was to stop, on this day or any other, so would everything you care about. It has happened before. The dawn stopped in the time of the dinosaurs ending their reign. It can happen again. The manufacture of life from light is not the only thing going on as our dawn sweeps over Asia. For every leaf that greets the dawn there's an ant that eyes the leaf; for the growing grass there are hungry calves, and for the fattening calves there are hungry men; for the sugar-swollen root there's a sugar-sucking fungus. For growth there's decay. For life, there is death. By the time the dawn has reached America, most of the people on the earth have woken and gone to work; some in the far east have retired for the night. During their working day, almost all of those who can see will have seen something green. In built up London (My World) I can count well over five hundred trees from my trip to Canary Wharf. We might not give a conscious thought to the omnipresent green, but at some level we will enjoy it. We will flock to it in parks on summer days and relax under its cool sun-dappled shade. The greenness of life is so important to us that our eyes are tuned to discriminate among its various hues more precisely than the shades of any other colour. The green, we know without thinking, is good.

But we don't just enjoy seeing the green. It shapes the possibilities of our lives. More than two billion of us will have tended to the eaters of the sun in some way today. We will have hoed the soil for them, fed the sun eaters fertilizer, cared for them, kept em warm, kept them watered. We will have picked their fruits, dug up their roots, fed them to our livestock and ourselves. We will have made their carcasses into fabrics and furniture and firewood. We will have tended to some of them for their beauty and for their smell. It is not We who rule the world. They do: the sun eaters are our true masters. How little we know it.

And even if we ignore these plants, these eaters of the sun completely, by locking ourselves away in concrete-steel jungles, we will still rely on yesterday's sun eaters. Everyday we burn thirty million tonnes of fossil fuel to generate our electricity and drive our cars and warm our homes. And all that power and warmth comes from sunlight eaten long ago - energy trapped in coal and oil. This planet is covered not in dust, or lava, or ice like the other lifeless planets in the solar system. It is covered in tiny photosynthetic machines, vibrant whirring electron transport chains embedded in membranes, that trap the sun and eat it. This is the most wonderful trick ever invented. And it was invented soon after life first emerged on earth. These machines are more numerous than the sands of the sea or the stars of the sky. But they are also short lived. The hard work of taking light and funnelling it into chemical reactions takes its toll on their bodies and mechanisms. Plants spend a significant amount of energy keeping their photosynthetic machinery in good repair, and in winter, when light levels drop, the factories in which photosynthesis takes place (the leaves) are no longer worth the repair bill and so are shed in their trillions. Cost cutting. You trample over these dead crispy factories in autumn. But the idea behind the machines, the idea written down in their DNA and broken out fresh each spring, is not so fragile. It is always there, the idea lives on. Bodies perish, but the idea and the design live forever.

Who would have thought this universe would give birth to creatures green and seemingly simple. Who would have thought life could be so creative. Who would have thought the nuclear-powered sun could be harnessed and subdued. Look! they are all around you. Do you not see? Pay a little more attention to these greens. Our bodies may be made of stardust but our lives are powered by starlight eaten by the sun eaters.

_____


Photobucket

Friday, May 15, 2009

The Origin of Life (part III)



If there can be said to exist a single formula; like the age-old secret of alchemists, a formula that makes all of life possible, then it is the following:

C02 + H2O  ---------  C6H12O6 + O2

Carbon dioxide + Water -------- Glucose (organic molecule) + Oxygen

It doesn’t look like much does it? It's rather unimpressive isn't it? How can such a simple formula hold the key to life? But it does! It makes you feel like a god just knowing it. A god surveying creation before him (or her). But enough of the purple prose. Time for some real science. But before we begin: A plea. I implore you to be patient. The science that follows will be tricky. I have tried my best to strip away any superfluousness, any excess fat, to simplify, to distill, so that what remains is the essence. But to truly understand will require a wee effort on your part. But the rewards; if I may be so bold to say, will be worth it. At the end of it all, if I can make you feel like a genius, if I can make you feel like a crazy lord of time surveying his dominion, than I will have succeeded. Let there be light!

We've already discussed that plants carry out the above reaction by harnessing solar energy during photosynthesis. We mentioned that photosynthesis is a hugely complex process involving numerous enzymes, proteins, electron carriers and an intricate membrane network. To reiterate: the first life on earth could not possibly have photosynthesised. Photosynthesis evolved much later. So, the question remains: How did the first life combine hydrogen with carbon dioxide to build the organic molecules necessary for it to exist?

I hinted that the ocean floor holds the key. Deep down below the surface; projecting from the sea bed like chimneys are hot water vents. These are like fissures or pimples on the earth’s skin where newly exposed rock, from deep within the bowels of the earth, reacts with sea water. It must be understood that water doesn’t just mix and percolate with the rock; it chemically reacts with it. The amount of water bound chemically to the rock in this way is astonishing. It is believed that it is equivalent to the entire volume of water in the oceans. As the sea floor expands from the movements of plate tectonics; these rocks which contain bound water, are ultimately plunged beneath a colliding plate. In what is known in geological parlance as a subduction zone.


Eventually, on the other side of the conveyor belt that powers the movement of the continents these rocks reach the surface of the sea bed. This is where the vents come in. The sea water that was once bound with the rocks is released again through the vents; but not as water (H2O) but as bubbling hydrogen gas.

At the turn of the millennium, scientists aboard the submersible Atlantis stumbled across just one of these vent systems spewing forth hydrogen gas. This vent system was nicknamed the 'lost city' and it had delicate finger like projections made of carbonate that reached up into the inky blackness. These projections gave the lost city a Gothic church look.


The projecting fingers themselves are porous, containing a maze of microscopic compartments like a bee hive. The compartments are 1/12mm in diameter (the same size as an average cell) and are teeming with life. The compartments are the home to colonies of industrious bacteria. The bacteria themselves provide the food source for other larger organisms that thrive in the vents. They are the 'producers' in this underwater food chain but the the key thing is that the entire ecosystem is supported by the reaction of hydrogen gas (H2) with carbon dioxide (CO2). Whereas on the surface this reaction has an initial energy requiring step in which hydrogen first has to be torn from water, but here, the reaction requires no such initial stage. Raw hydrogen bubbling from the ground as a gas is a rare gift on our planet, and life is normally obliged to seek out occult supplies, bound in tight molecular grip to other atoms, as in water or hydrogen sulphide. The reaction occurs painfully slowly, but from the view of thermodynamics it is a free lunch. In fact is is better then a free lunch. You see, not only does the reaction of hydrogen and carbon dioxide occur spontaneously but it also releases energy as a result - energy that can be used to power other reactions. It's like walking into a restaurant, having a meal, and then being paid for it! - the ultimate free lunch. It takes such a free lunch to get life going on a planet. These vents fit the bill as a hatchery for life on earth. They generate organic molecules. They have porous compartments, which can concentrate any organic molecules formed, making the assembly of polymers (long chained molecules) like RNA (Ribonucleic acid - simpler cousin of the more famous Deoxyribonucleic acid DNA). The vents are long lived; the lost city itself has been venting for at least 40,000 years. The walls of the vents contain iron-sulphur minerals which can act as catalysts to speed up and promote the reactions further.

But I hear the whispers of naysayers. I know what you're thinking: such vents are all very well, but how did life progress from such natural reactors to the complex, marvelous tapestry of invention and ingenuity that we see around us? The answer, of course, is unknown but there are clues within all of us. A clue to the past. Yes, within each of us is a 'smoking gun', an ancient remnant of the origin of life itself. All life on earth without exception has within it a set of deeply conserved biochemical reactions, like a living fossil, but not a fossil of bones, nay a fossil of biochemistry. The same reactions that occured at the dawn of life, also occur in the underwater vents and also occur inside your body! Amazing huh? From Bacteria to Penguin. From woolly Mammoth to Chimpanzee we all contain a clue to our primordial past. Don't believe me? I'll show you. We now turn to these for the next step in our wonderful story.

All life on earth shares certain qualities. All living things are composed of cells (with the exception of viruses). All cells in all living things on earth have genes made of DNA; all DNA codes for proteins by means of a universal genetic code. All living things also share the same energy currency, known as ATP. This chemical is like a £10 note, used to 'pay' for all kinds of work that needs to be done to keep life alive. We can infer that all living things inherited these qualities from the first remote common ancestor. All life today also shares a common core of biochemical reactions, at the heart of which is a little cycle of reactions that is the bane of many a biochemistry student: the Krebs cycle! The Krebs cycle occupies hallowed ground in biochemistry - but for me it was something to be rote learned for exams and then quietly forgotten. Yet, within this ancient and dusty cycle of reactions lies the answer to the meaning of life - or, if not that, then at least how it got started!



(The Krebs Cycle - a pain in the ass for all biochemistry students)

I don’t expect you to understand the details. The main things to take are:

  • The main purpose of the Krebs cycle is respiration i.e. to generate energy
  • At the top you can see a chemical called Pyruvate which is shunted into our cycle
  • ATP (the cellular currency of energy) is generated as the wheel turns. The ATP is then used to power life.
  • Carbon dioxide and water are produced as waste products of this cycle.

What has any of this got to do with anything you're wondering? Let me explain. At the top of the cycle is a chemical called Pyruvate. Where does Pyruvate come from?



Don't worry about the details (!). All you need to do is look at the top left and read out the name of the first chemical you see...exactly, glucose. And the last chemical at the bottom...pyruvate.

So glucose is absorbed into the body and is converted into Pyruvate via the above series of reactions. Pyruvate in turn is shunted into the Krebs cycle thereby generating energy and releasing carbon dioxide and water as waste products. This is your basic respiration you learnt at school. But wait a minute! Isn’t this the opposite of the reaction we want? Aren’t we trying to combine carbon dioxide (CO2) and water (H20) to make glucose? Aren't these cycle of reactions breaking down glucose to generate C02 and H20. Yes, true but if you look at the cycle again you'll see double arrows between the reactants. This means that the Krebs cycle is reversible. It can run backwards.

Here is a simple version of the cycle to explain my point:




Glucose enters at the top to be broken down into water, carbon dioxide and ATP. If we run it in reverse we can combine water and carbon dioxide, and with the input of some energy, make glucose!

And he said: 'Let there be life, and life sprawled forth from the vents'

Normally the Krebs cycle is used in respiration to break down glucose. But it can also run in reverse to make glucose and other organic molecules. The reversal of this cycle is common in primitive bacteria - especially those found living in hydrothermal vents. It is clearly a primitive way of converting carbon dioxide and water into the building blocks of life. The other amazing thing about the cycle is that it can spin of its own accord. It is thermodynamically stable. In other words it was not invented by living things, it is chemistry that already existed before life emerged. Life simply took the naturally occurring reactions occurring in the ocean vents and made them its own. When life emerged it 'conducted' a score that already existed! Once the Krebs cycle got spinning, side reactions would have been inevitable, giving amino acids and proteins. How much of the core metabolism of life on earth arose spontaneously, and how much is a later product of genes and proteins is an interesting question and quite beyond the scope of this post. But I would hazard a guess that if you were to set up the Krebs cycle in a test tube, give it a spark of energy, and a wollop of inspiration, a whole bunch of proteins and nucleic acids would be synthesised spontaneously. It is a thermodynamic inevitability.

This paints an extraordinary portrait of the first life on earth - our first ancestor. She wasn't some free living, pulsating, moving, throbbing cell but a rocky labyrinth of mineral cells, lined with catalytic walls of iron, sulphur and nickel. The first life was a porous rock that generated complex molecules and energy right up to the formation of proteins and DNA itself. If this doesn’t shake you and evaporate the anaesthetic of familiarity that hovers above you in your daily life, then I don’t know what will. Do you feel like a genius now?

We now turn to DNA and cells. How did they arise from this queer and wonderful ancestor of ours. This rocky labyrinth of mineral cells...


Open your eyes (Snow patrol)